What Are GLP-1 Medications Made Of, really?
- Deion DeLeon
- 2 days ago
- 3 min read
By Deion DeLeon - Functional Fitness Professional
GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) are not just simple appetite suppressants.
These drugs are genetically engineered peptide-based molecules, built to mimic your body’s own hormones — but in an amplified and long-lasting form.
How They're Made
The base of these medications is a synthetic peptide, which is a small chain of amino acids that mimics the natural GLP-1 hormone your intestines release after eating.
But here’s where it gets intense: To make it last longer in your bloodstream, scientists modify these peptides by attaching fatty acid chains and stabilizing molecules, so the drug doesn't break down too quickly. This chemical engineering allows the medication to stay active for days — even up to a week with just one dose.
Some formulations (like tirzepatide) also stimulate GIP receptors, another hormonal pathway that amplifies the body’s insulin response and further slows digestion.
“It Works Like Poison” — And That’s Not a Metaphor
While these drugs aren’t literally classified as poisons, their effects can mimic toxic responses in the body — especially when misused or not medically supervised.
Here’s why:
🔄 Extreme Slowing of Gastric Emptying
GLP-1 drugs drastically slow down digestion, sometimes to the point where food sits in the stomach for twice as long as it should.
In some people, this triggers gastroparesis — a dangerous condition where your stomach muscles literally stop working properly, leading to:
Severe bloating
Nausea
Vomiting undigested food hours later
Malnutrition and electrolyte imbalance
In essence, you’re tricking your digestive system into “stall mode,” and in some people, it never resets.
Hijacking the Brain’s Reward System
These drugs directly affect the hypothalamus — the brain’s control center for hunger, cravings, and reward.
They blunt your natural dopamine reward loop, making food less pleasurable, and cravings less intense.
Sounds helpful? Sure — but there’s a trade-off.
Some users report:
Depression-like symptoms
Emotional numbness
Loss of interest in eating — even when it’s healthy food
Eating disorders or disordered eating patterns
This neurological disruption is chemically induced, not learned through mindset or habit building.
Foreign Molecules in a Fragile System
GLP-1 drugs are lab-made analogues — similar but not identical to your body’s own hormones. They are foreign compounds, which means your immune system, pancreas, gastrointestinal tract, and endocrine system may react to them unpredictably.
Some rare but real risks include:
Pancreatitis (potentially fatal)
Thyroid C-cell tumors (seen in rodent studies)
Gallbladder dysfunction
Muscle atrophy, especially with rapid weight loss and no resistance training
Loss of lean mass, which can lower metabolic rate and increase the chance of rebound weight gain
So… Why Is This Still Prescribed?
Because for people with type 2 diabetes or life-threatening obesity, the benefits of short-term use may outweigh the risks — when managed with:
Doctor supervision
Proper blood work monitoring
A medically guided nutrition and training plan
But if you’re relying on these drugs without making lifestyle changes, you’re essentially:
“Using a pharmaceutical hammer to patch a lifestyle hole.”
You’re chemically altering your body’s ability to eat and digest without building the skills or structure needed to sustain health long-term.
Bottom Line: This Isn’t a Biohack — It’s a Bio-override
GLP-1s are not vitamins. They’re not protein shakes. They are highly engineered metabolic disruptors that rewire your hunger, digestion, and hormonal balance.
Used responsibly and with medical guidance, they can help people get back on track.
Used recklessly, they can act more like a slow poison than a solution.
If you don’t pair these drugs with:
Whole food nutrition
Consistent resistance training
Sleep optimization
Behavioral change
…you’re just buying temporary success with long-term consequences.
DM me “REAL FAT LOSS” On Instagram @deion_deleon217
…if you want to stop depending on short-term fixes and build a sustainable fat-loss plan through nutrition coaching, training, and accountability — no matter where you’re starting from.
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